Mouse Model for Peritoneal Fibrosis (PF)
PF; Peritoneal Fibrosis
- Product No.DSI819Mu01
- Organism SpeciesMus musculus (Mouse) Same name, Different species.
- Prototype SpeciesHuman
- SourceIntraperitoneal injection(I.P) of high glucose dialysate
- Model Animal StrainsKM mice (SPF), healthy, male, 6~8 weeks
- Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
- Modeling Period4w
- Modeling Method1.Mice were intraperitoneally injected with 4.25% high glucose dialysate (100ml/kg) and LPS (0.1mg/kg) once a day for four weeks.
2.Measure the peritoneal function and take tissue from the parietal peritoneum and visceral peritoneum (mesentery) for relevant indicators. - ApplicationsUsed to study the process and pharmacodynamics of peritoneal fibrosis
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- UOM Each case
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US$ 240
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Model Evaluation of the Mouse Model for Peritoneal Fibrosis (PF)
1. Observe the changes in peritoneal thickness of experimental animals in each group using Masson staining. Compared with the normal control group, Masson staining showes that the model group had significantly thickened peritoneum, increased extracellular matrix, increased collagen fibers, and significant changes in peritoneal fibrosis.
Pathological Results of the Mouse Model for Peritoneal Fibrosis (PF)
2. Western blot and Q-PCR detection of fibronectin (FN) and smooth muscle protein( α- SMA), E. cadherin, expression of type I collagen (Col I).
Cytokines Level of the Mouse Model for Peritoneal Fibrosis (PF)
Statistical Analysis of the Mouse Model for Peritoneal Fibrosis (PF)
SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.
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Immunohistochemistry (IHC) Experiment Service
Small Animal In Vivo Imaging Experiment Service
Small Animal Micro CT Imaging Experiment Service
Small Animal MRI Imaging Experiment Service
Small Animal Ultrasound Imaging Experiment Service
Transmission Electron Microscopy (TEM) Experiment Service
Scanning Electron Microscope (SEM) Experiment Service
Learning and Memory Behavioral Experiment Service
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Nitric Oxide Assay Kit (A012)
Nitric Oxide Assay Kit (A013-2)
Total Anti-Oxidative Capability Assay Kit(A015-2)
Total Anti-Oxidative Capability Assay Kit (A015-1)
Superoxide Dismutase Assay Kit
Fructose Assay Kit (A085)
Citric Acid Assay Kit (A128 )
Catalase Assay Kit
Malondialdehyde Assay Kit
Glutathione S-Transferase Assay Kit
Microscale Reduced Glutathione assay kit
Glutathione Reductase Activity Coefficient Assay Kit
Angiotensin Converting Enzyme Kit
Glutathione Peroxidase (GSH-PX) Assay Kit
Cloud-Clone Multiplex assay kits
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Catalog No. | Organism species: Mus musculus (Mouse) | Applications (RESEARCH USE ONLY!) |
DSI819Mu01 | Mouse Model for Peritoneal Fibrosis (PF) | Used to study the process and pharmacodynamics of peritoneal fibrosis |