Mouse Model for Glomerular Nephritis (GN)

Glomerulonephritis

• Urinary system

• Product No.UDSI628Mu04
• Organism SpeciesMus musculus (Mouse) Same name, Different species.
• • All
  • Human
  • Mouse
  • Rat
  • Cavia
  • Rabbit
  • Simian
  • Caprine
  • Ovine
  • Equine
  • Bovine
  • Porcine
  • Gallus
  • Canine
  • Others
  • Multi-species
  • Pan-species
• Prototype SpeciesHuman
• SourceNon-infectious Glomerulonephritis
• Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 8~10weeks, body weight:30g~35g.
• Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
• Modeling Period4-6 weeks
• Modeling MethodWeight of 18 ~ 20 g male KM mice, when,7,10 1 day according to the dose of 2 mg/mlPBS by intraperitoneal injection of sephadex gel suspension liquid 0.4 ml/time. Since 3 weeks, the mice tail antigen of dextran solution, given intravenously, 0.4 ml/time, 2 times a week, and the injection to 8 weeks continuously, 24 h after the last one antigen solution injection, bladder puncture mice, made of urine urine protein qualitative test. Animals bleeding to death after anesthesia, renal tissue samples for frozen section in mice, sheep with fluorescein isothiocyanate) mark against mice IgA direct fluorescent dye, on fluorescence microscope detection IgA antibodies. In kidney tissues, with 2.5% glutaraldehyde and 1% osmic acid, epoxy resin embedding, ultrathin slices, uranium acetate and lead citrate staining, were observed under tem.
• Applicationsn/a
• Download n/a
• UOM Each case
• FOB US$
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