Rat Model for Tourette Syndrome (TS)
Tourette's
- Product No.DSI550Ra01
- Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
- Prototype SpeciesHuman
- SourceInduced by 3,3 '-iminodipropionitrile(IDPN)
- Model Animal StrainsSD Rats(SPF), healthy, male, bodyweight:180g~200g
- Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group (Tiapride Hydrochloride )and Test drug group (three doses) n=15.
- Modeling Period7d
- Modeling Method1. The rats were injected intraperitoneally with 3,3 '-iminodipropionitrile(IDPN), and the dose: 300 mg/(kg.d) for continuous administration for 7 days.
2. After modeling, the rats were given intragastric administration at the same time every morning. The blank group and model group were given normal saline. The intragastric dose was 1mL/100g. - ApplicationsUsed to screen drugs for preventing and treatment for Tourette Syndrome
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FOB
US$ 200
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Model Evaluation of the Rat Model for Tourette Syndrome (TS)
Behavioral experiment evaluation criteria
1. Motion behavior assessment standard:
0 points: quiet or normal activity;
1 points: over excited;
2 points: increase the behavior of inquiry, non continuous nasal suction;
3 points: keep running;
4 points: stop running with startle.
2. Stereotyped behavior assessment standard: according to the Diamond score
0 points: no stereotyped movement;
1 points: the body rotation behavior (rotation clockwise or counterclockwise);
2 points: head and neck movement up and down too much (an abnormal movement of head and neck and vertical direction);
3 points: head and neck movement up and down too much and rotating motion;
4 points: head to the side of the pendulum, with head and neck movement up and down too much.
Behavioral assessment time: the behavioral experiment was performed every other day for 7 days after modeling, and a total of 5 behavioral tests were performed.
Pathological Results of the Rat Model for Tourette Syndrome (TS)
Cytokines Level of the Rat Model for Tourette Syndrome (TS)
Dopamine(DA), Dopamine receptor 2(D2R):
After the last administration of fasting but free drinking water at night, 5 rats in each group were randomly selected, after the end of the blood into the EDTA anticoagulant tube, frozen centrifugation (3000 rpm, 10 minutes), take the supernatant stored at -80℃.
ELISA kit was used to detect the content of DA and D2R in serum and striatum
Statistical Analysis of the Rat Model for Tourette Syndrome (TS)
SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.
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Nitric Oxide Assay Kit (A013-2)
Total Anti-Oxidative Capability Assay Kit(A015-2)
Total Anti-Oxidative Capability Assay Kit (A015-1)
Superoxide Dismutase Assay Kit
Fructose Assay Kit (A085)
Citric Acid Assay Kit (A128 )
Catalase Assay Kit
Malondialdehyde Assay Kit
Glutathione S-Transferase Assay Kit
Microscale Reduced Glutathione assay kit
Glutathione Reductase Activity Coefficient Assay Kit
Angiotensin Converting Enzyme Kit
Glutathione Peroxidase (GSH-PX) Assay Kit
Cloud-Clone Multiplex assay kits
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Catalog No. | Organism species: Rattus norvegicus (Rat) | Applications (RESEARCH USE ONLY!) |
DSI550Ra01 | Rat Model for Tourette Syndrome (TS) | Used to screen drugs for preventing and treatment for Tourette Syndrome |