Mouse Model for Allergic Rhinitis (AR)

Hay fever

• Eye, ear, nose, throat and oral systems

• Product No.DSI584Mu01
• Organism SpeciesMus musculus (Mouse) Same name, Different species.
• • All
  • Human
  • Mouse
  • Rat
  • Cavia
  • Rabbit
  • Simian
  • Caprine
  • Ovine
  • Equine
  • Bovine
  • Porcine
  • Gallus
  • Canine
  • Others
  • Multi-species
  • Pan-species
• Prototype SpeciesHuman
• SourceInduced by OVA sensitization and nasal drip method
• Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g
• Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and three Test drug group.
• Modeling Period4-6 weeks
• Modeling Method1.Preparation of sensitizer
  Alum sensitizing adjuvant: After mixing 10% alum solution (dissolved in double distilled water) 2ml and 5% OVA (dissolved in PBS) 2ml, the PH was adjusted to 6.5 with NAOH, and the solution was incubated at room temperature for 60min. 750r/min, centrifuged for 5min, the supernatant was removed and redissolved in 2ml PBS. Each mouse was intraperitoneally injected with 200ul for sensitization.
  
  2. Drug administration and modeling
  0.2ml OVA suspension was intraperitoneally injected on days 1-11, respectively.
  
  3. Nasal drip stimulation
  Day 12-20, 40ul/ nostril nasal drops were given daily for 9 consecutive days.
• ApplicationsDisease Model
• Download n/a
• UOM Each case
• FOB US$ 160
  For more details, please contact local distributors!