Presenilin 1 (PSEN1)
[ Edit ]
FAD; AD3; PS1; PSNL1; S182; Alzheimer Disease 3; Protein S182; Presenilin-1 CTF12
 HGNC 9508
 MGI 1202717
 PubMed 22461631
 RGD 3425
 UniProt P49768
 USCN C200
 Wiki PSEN1
Presenilin 1 (PSEN1)
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma secretase activity or themselves are protease enzymes. Multiple alternatively spliced transcript variants have been identified for this gene, the full-length natures of only some have been determined.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC200Hu01 Recombinant Presenilin 1 (PSEN1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAC200Hu21 Monoclonal Antibody to Presenilin 1 (PSEN1) WB, ICC, IHC-P, IHC-F, ELISA
PAC200Hu01 Polyclonal Antibody to Presenilin 1 (PSEN1) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC200Hu ELISA Kit for Presenilin 1 (PSEN1) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC200Mu01 Recombinant Presenilin 1 (PSEN1) SDS-PAGE; WB; ELISA; IP.
RPC200Mu02 Recombinant Presenilin 1 (PSEN1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC200Mu01 Polyclonal Antibody to Presenilin 1 (PSEN1) WB, ICC, IHC-P, IHC-F, ELISA
PAC200Mu02 Polyclonal Antibody to Presenilin 1 (PSEN1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC200Mu ELISA Kit for Presenilin 1 (PSEN1) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC200Ra01 Recombinant Presenilin 1 (PSEN1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAC200Ra21 Monoclonal Antibody to Presenilin 1 (PSEN1) WB, ICC, IHC-P, IHC-F, ELISA
PAC200Ra01 Polyclonal Antibody to Presenilin 1 (PSEN1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC200Ra ELISA Kit for Presenilin 1 (PSEN1) Enzyme-linked immunosorbent assay