Chang et al. (2006) found that human umbilical vein endothelial cells in which HDAC7 (HDAC7A) expression was suppressed by RNA interference failed to adhere to each other. Microarray analysis showed that HDAC7 suppression led to dysregulation of numerous genes encoding extracellular matrix and adhesion proteins, including 6.5-fold upregulation of MMP10 and 8.6-fold downregulation of the MMP10 inhibitor, TIMP1.

Chang et al. (2006) found that HDAC7 downregulated MMP10 by associating with MEF2 , an MMP10 transcriptional activator. Hdac7 deletion in mice, which was embryonic lethal due to widespread vascular damage, resulted in dramatic upregulation of Mmp10 in the perivascular region and downregulation of Timp1 in endothelial cells.