Ferroportin (FPN)

SLC40A1; FPN1; HFE4; IREG1; MTP1; SLC11A3; Solute Carrier Family 40,Member 1; Iron-Regulated Transporter

Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. Recent research suggests that ferroportin is inhibited by hepcidin, which therefore is the "master regulator" of human iron metabolism. Hepcidin binds to ferroportin, and results in the internalisation of ferroportin within the cell, followed by degradation by the proteasome. This results in retention of iron within the cell, and a reduction in iron levels within the plasma. This is part of the mechanism that causes anaemia of chronic disease; hepcidin is released from the liver in response to inflammatory cytokines, namely interleukin-6, which results in an increased hepcidin concentration and a consequent decrease in plasma iron levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC489Hu01 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC489Hu01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
MAC489Hu22 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
LAC489Hu71 Biotin-Linked Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC.
MAC489Hu21 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
MAC489Hu24 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
MAC489Hu26 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
LAC489Hu76 Biotin-Linked Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC.
Assay Kits SEC489Hu ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.
CEC489Hu ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC489Mu01 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPC489Mu02 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
CPC489Mu21 OVA Conjugated Ferroportin (FPN) Immunogen; SDS-PAGE; WB.
Antibodies PAC489Mu01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
PAC489Mu02 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
Assay Kits SEC489Mu ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC489Mu CLIA Kit for Ferroportin (FPN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC489Ra01 Recombinant Ferroportin (FPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC489Ra01 Polyclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
MAC489Ra21 Monoclonal Antibody to Ferroportin (FPN) WB; IHC; ICC; IP.
Assay Kits SEC489Ra ELISA Kit for Ferroportin (FPN) Enzyme-linked immunosorbent assay for Antigen Detection.