Cytochrome P450 1A1 (CYP1A1)
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CYP1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; Cytochrome P450,Subfamily I(Aromatic Compound-Inducible),Polypeptide 1
 HGNC 2595
 MGI 88588
 PubMed 11505220
 RGD 2458
 UniProt P04798
 USCN D295
 Wiki CYP1A1
Cytochrome P450 1A1 (CYP1A1)
CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons.
CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzopyrene (BP), by transforming it to an epoxide. In this reaction, the oxidation of benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide, which can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol. Finally CYP1A1 catalyses this intermediate to form BP-7,8-dihydrodiol-9,10-epoxide, which is the ultimate carcinogen.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD295Hu01 Recombinant Cytochrome P450 1A1 (CYP1A1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAD295Hu21 Monoclonal Antibody to Cytochrome P450 1A1 (CYP1A1) WB, ICC, IHC-P, IHC-F, ELISA
PAD295Hu01 Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SED295Hu ELISA Kit for Cytochrome P450 1A1 (CYP1A1) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD295Mu01 Recombinant Cytochrome P450 1A1 (CYP1A1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAD295Mu01 Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD295Ra01 Recombinant Cytochrome P450 1A1 (CYP1A1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAD295Ra21 Monoclonal Antibody to Cytochrome P450 1A1 (CYP1A1) WB, ICC, IHC-P, IHC-F, ELISA
PAD295Ra01 Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SED295Ra ELISA Kit for Cytochrome P450 1A1 (CYP1A1) Enzyme-linked immunosorbent assay