Rat Model for Polycystic Ovarian Syndrome (PCOS)
Polycystic Ovary Syndrome
- Product No.DSI546Ra01
- Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
- Prototype SpeciesHuman
- SourceTestosterone Propionate induced PCOS
- Model Animal StrainsSFF SD rats,healthy, female, ages: 6~8 weeks, about 200g.
- Modeling GroupingRandomly divided into three groups: model group (n = 30) , control group (n = 30) and the blank group (n = 30).
- Modeling Period6~8 weeks
- Modeling Method1 gram Testosterone Propionate powder(CAS:57-85-2) is dissolved in 100mL injection of sterile soybean oil, with 10mg/mL oil.
Model group rats with testosterone propionate, according to the body weight of 1mg/100g dose, continuous injection of 4-8 weeks; the control group received the same volume of sterile according to the weight of soybean oil, continuous injection of 4-8 weeks; blank group with no treatment. - ApplicationsDisease Model
- Download n/a
- UOM Each case
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FOB
US$ 240
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Model Evaluation of the Rat Model for Polycystic Ovarian Syndrome (PCOS)
1. Vaginal smear test for estrous cycle
The smear of vaginal epithelial cell in control group rats showed a periodic change, cycle in 4-5 days, changes of estrous cycle; vaginal epithelial cells of rats in model group continued hyperkeratosis, it always in diestrus, estrous cycle of lost.
2. Determination of serum sex hormones
Biochemical tests showed that the level of testosterone(T) in model group increased significantly, follicle stimulating hormone(FSH), luteinizing hormone(LH), prolactin(RPL) level decreased.
Pathological Results of the Rat Model for Polycystic Ovarian Syndrome (PCOS)
3. Changes in ovarian tissue
In model group, the pathological changes of the ovarian structure and ovarian follicles seen in cystic dilatation and showed cystic pathological changes, locking multiple follicular granulosa cells, retention cyst obviously reduced, theca cells increased
Cytokines Level of the Rat Model for Polycystic Ovarian Syndrome (PCOS)
Statistical Analysis of the Rat Model for Polycystic Ovarian Syndrome (PCOS)
SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.
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Nitric Oxide Assay Kit (A013-2)
Total Anti-Oxidative Capability Assay Kit(A015-2)
Total Anti-Oxidative Capability Assay Kit (A015-1)
Superoxide Dismutase Assay Kit
Fructose Assay Kit (A085)
Citric Acid Assay Kit (A128 )
Catalase Assay Kit
Malondialdehyde Assay Kit
Glutathione S-Transferase Assay Kit
Microscale Reduced Glutathione assay kit
Glutathione Reductase Activity Coefficient Assay Kit
Angiotensin Converting Enzyme Kit
Glutathione Peroxidase (GSH-PX) Assay Kit
Cloud-Clone Multiplex assay kits
Related products
Catalog No. | Organism species: Rattus norvegicus (Rat) | Applications (RESEARCH USE ONLY!) |
DSI546Ra01 | Rat Model for Polycystic Ovarian Syndrome (PCOS) | Disease Model |
TSI546Ra31 | Rat Ovary Tissue of Polycystic Ovarian Syndrome (PCOS) | Paraffin slides for pathologic research: IHC,IF and HE,Masson and other stainings |