Zinc Finger Protein 649 (ZNF649)
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 HGNC 25741
 PubMed 15950191
 UniProt Q9BS31
 USCN N139
 Wiki ZNF649
Zinc Finger Protein 649 (ZNF649)
ZNF649 encodes a deduced 505-amino acid protein that contains an N-terminal Kruppel-associated box (KRAB) belonging to the classic KRAB-AB box, and 10 C2H2 zinc finger motifs that extend to the end of the protein sequence. Northern blot analysis of multiple human tissues detected expression of a 3.2-kb ZNF649 transcript in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas; in adult tissues, the transcript was detected predominantly in heart, skeletal muscle, and brain, and at lower levels in other tissues. A GFP-ZNF649 fusion protein localized primarily in the nucleus of COS-7 cells.ZNF649 can suppress the transcriptional activities of SRE and AP1 transcription factors. Deletion analysis with truncated proteins indicated that the KRAB domain is required for the repressive activity of ZNF649.
Organism species: Homo sapiens (Human)
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a