Xeroderma Pigmentosum, Complementation Group A (XPA)
XP-A; XPAC; XP1; DNA repair protein complementing XP-A cells
XPA encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. The deduced 273-amino acid protein has a calculated molecular mass of 31 kD. The human protein is 95% similar to the mouse protein and contains several alpha-helices and a zinc-finger motif, consistent with a DNA-binding protein. Two mRNAs, 1.3-1.4 kb and 1.0-1.1 kb, were detected in normal human cells. Sequence analysis identified a truncated XPA protein that could be translated from an ATG present at position 176, which retained sufficient function to partially restore the DNA repair defect in XPA cells. A 1.0-1.1-kb mouse Xpa mRNA was also identified.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE744Hu01 | Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA) | ELISA Kit Customized Service Offer |