X-Ray Repair Cross Complementing 1 (XRCC1)
RCC; DNA repair protein XRCC1
XRCC1 is a DNA repair protein.involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.Inhibition of XRCC1 phosphorylation by mutation of the CK2 phosphorylation sites or by preventing CK2 activity using a highly specific inhibitor ablated the rapid repair of cellular DNA single-strand breaks by XRCC1. These data identified a direct role for CK2 in the repair of chromosome DNA strand breaks and in maintaining genetic integrity.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPG148Hu01 | Recombinant X-Ray Repair Cross Complementing 1 (XRCC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAG148Hu01 | Polyclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1) | WB; IHC; ICC; IP. |
Assay Kits | SEG148Hu | ELISA Kit for X-Ray Repair Cross Complementing 1 (XRCC1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPG148Mu01 | Recombinant X-Ray Repair Cross Complementing 1 (XRCC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for X-Ray Repair Cross Complementing 1 (XRCC1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for X-Ray Repair Cross Complementing 1 (XRCC1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant X-Ray Repair Cross Complementing 1 (XRCC1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to X-Ray Repair Cross Complementing 1 (XRCC1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for X-Ray Repair Cross Complementing 1 (XRCC1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for X-Ray Repair Cross Complementing 1 (XRCC1) | ELISA Kit Customized Service Offer |