Wiskott Aldrich Syndrome Protein (WASP)
WAS; IMD2; THC; Eczema-Thrombocytopenia
The Wiskott-Aldrich Syndrome Protein (WASp) is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon Cdc42 and PIP2 acting to disrupt this interaction causing the WASp protein to 'open'.
This exposes a domain near the WASp C-Terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin. WASp is the founding member of a gene family which also includes the broadly expressed N-WASP (neuronal Wiskott-Aldrich Syndrome protein), and Scar.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB917Hu01 | Recombinant Wiskott Aldrich Syndrome Protein (WASP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB917Hu01 | Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Wiskott Aldrich Syndrome Protein (WASP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB917Ra01 | Recombinant Wiskott Aldrich Syndrome Protein (WASP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB917Ra01 | Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) | ELISA Kit Customized Service Offer |