TEK Tyrosine Kinase, Endothelial (Tie2)
TEK; CD202b; VMCM1; CD202-B; Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 2; Venous Malformations Multiple Cutaneous And Mucosal
 HGNC 11724
 MGI 98664
 OMIM 600221
 RGD 620980
 UCSC uc003zqi.2
 UniProt Q02763
 USCN 90126
TEK Tyrosine Kinase, Endothelial (Tie2)
Tie-2 is a receptor tyrosine kinase that is expressed primarily on endothelial cells (ECs) and plays a critical role in vascular development. The Tie-2 gene encodes a protein of 1122 amino acids. The extracellular region has three distinct structural motifs including two immunoglobulin (Ig)-like loops separated by three EGF-like repeats, and three repeats with fibronectin type III homology located after the second Ig loop. The intracellular portion of Tie-2 contains two tyrosine kinase domains that, when phosphorylated, interact with a number of binding partners including Grb2, Grb7, Grb14, Shp2, the p85 subunit of phosphatidylinositol 3-kinase (PI3K), and Dok-R. Deletion of the last 16 amino acids of the intracellular C-terminus results in increased levels of autophosphorylation, suggesting that it may play an autoinhibitory role.
Research reagent products of TEK Tyrosine Kinase, Endothelial (Tie2)
Organism
Protein
Antibody
ELISA Kit
CLIA Kit
Catalog Manual McAb PcAb Catalog Manual Catalog Manual
Homo sapiens (Human)rP90126Hu01n/amA90126Hu22pA90126Hu01 sE90126HuPDFn/an/a
Mus musculus (Mouse)rP90126Mu01n/an/apA90126Mu01 sE90126MuPDFn/an/a
Rattus norvegicus (Rat)rP90126Ra01n/an/apA90126Ra01 sE90126RaPDFn/an/a
Sus scrofa; Porcine (Pig)n/an/an/an/a n/an/an/an/a
Bos taurus; Bovine (Cattle)rP90126Bo01n/an/apA90126Bo01 sE90126Bon/an/an/a
Ovis aries; Ovine (Sheep)n/an/an/an/a n/an/an/an/a
Danio rerio (Zebrafish)rP90126Fi01n/an/apA90126Fi01 sE90126Fin/an/an/a