TEK Tyrosine Kinase,Endothelial(Tie2)
TEK; CD202b; VMCM1; CD202-B; Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 2; Venous Malformations Multiple Cutaneous And Mucosal
 H U G O 11724
M   G   I 98664
O M I M 600221
R   G   D 620980
U C S C uc003zqi.2
UniProt Q02763
USCNK 90126
TEK Tyrosine Kinase,Endothelial(Tie2)
Tie-2 is a receptor tyrosine kinase that is expressed primarily on endothelial cells (ECs) and plays a critical role in vascular development. The Tie-2 gene encodes a protein of 1122 amino acids. The extracellular region has three distinct structural motifs including two immunoglobulin (Ig)-like loops separated by three EGF-like repeats, and three repeats with fibronectin type III homology located after the second Ig loop. The intracellular portion of Tie-2 contains two tyrosine kinase domains that, when phosphorylated, interact with a number of binding partners including Grb2, Grb7, Grb14, Shp2, the p85 subunit of phosphatidylinositol 3-kinase (PI3K), and Dok-R. Deletion of the last 16 amino acids of the intracellular C-terminus results in increased levels of autophosphorylation, suggesting that it may play an autoinhibitory role.
 ELISA Kits(Enzyme-linked immunosorbent assay Kits)
Catalog Product Name Species Packing Price Manual
E90126HuELISA Kit for Human TEK Tyrosine Kinase,Endothelial(Tie2)Human96T$700   PDF
E90126MuELISA Kit for Mouse TEK Tyrosine Kinase,Endothelial(Tie2)Mouse96T$720   PDF
E90126RaELISA Kit for Rat TEK Tyrosine Kinase,Endothelial(Tie2)Rat96T$760   PDF
E90126PoELISA Kit for Porcine TEK Tyrosine Kinase,Endothelial(Tie2)Pig96T$840   n/a
E90126BoELISA Kit for Bovine TEK Tyrosine Kinase,Endothelial(Tie2)Cattle96T$840   PDF
E90126FiELISA Kit for Fish TEK Tyrosine Kinase,Endothelial(Tie2)Fish96T$1000   PDF
 Antibodies
Catalog Product Name Species Packing Price Manual
A90126HuAntibody to Human TEK Tyrosine Kinase,Endothelial(Tie2)Humann/an/a   n/a
A90126MuAntibody to Mouse TEK Tyrosine Kinase,Endothelial(Tie2)Mousen/an/a   n/a
A90126RaAntibody to Rat TEK Tyrosine Kinase,Endothelial(Tie2)Ratn/an/a   n/a
A90126PoAntibody to Porcine TEK Tyrosine Kinase,Endothelial(Tie2)Porcinen/an/a   n/a
A90126BoAntibody to Bovine TEK Tyrosine Kinase,Endothelial(Tie2)Bovinen/an/a   n/a
A90126FiAntibody to Fish TEK Tyrosine Kinase,Endothelial(Tie2)Fishn/an/a   n/a
 CLIA Kits(Chemiluminescent immunoassay Kits)
Catalog Product Name Species Packing Price Manual
C90126HuCLIA Kit for Human TEK Tyrosine Kinase,Endothelial(Tie2)Humann/an/a   n/a
C90126MuCLIA Kit for Mouse TEK Tyrosine Kinase,Endothelial(Tie2)Mousen/an/a   n/a
C90126RaCLIA Kit for Rat TEK Tyrosine Kinase,Endothelial(Tie2)Ratn/an/a   n/a
C90126PoCLIA Kit for Porcine TEK Tyrosine Kinase,Endothelial(Tie2)Pign/an/a   n/a
C90126BoCLIA Kit for Bovine TEK Tyrosine Kinase,Endothelial(Tie2)Cattlen/an/a   n/a
C90126FiCLIA Kit for Fish TEK Tyrosine Kinase,Endothelial(Tie2)Fishn/an/a   n/a