Triple Functional Domain Protein (TRIO)

Tgat; ARHGEF23; PTPRF-interacting protein

The TRIO protein contains 3 functional domains: a serine/threonine kinase domain and 2 guanine nucleotide exchange factor (GEF) domains for the family of Rho-like GTPases, specific for Rac1 and RhoA, respectively. These domains suggest that this enzyme may play a key role in several signaling pathways that control cell proliferation.
Overexpression of their N-terminal GEF domains enhanced secretion from immature granules, depleting cells of secretory cargo in the absence of secretagogue. This response required GEF activity and was mimicked by kalirin/Trio substrates Rac1 and RhoG. Selective pharmacologic inhibition of endogenous GEF activity decreased secretagogue-independent release of hormone precursors, causing accumulation of product peptide in mature secretory granules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Triple Functional Domain Protein (TRIO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Triple Functional Domain Protein (TRIO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Triple Functional Domain Protein (TRIO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Triple Functional Domain Protein (TRIO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triple Functional Domain Protein (TRIO) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Triple Functional Domain Protein (TRIO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Triple Functional Domain Protein (TRIO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Triple Functional Domain Protein (TRIO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Triple Functional Domain Protein (TRIO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triple Functional Domain Protein (TRIO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Triple Functional Domain Protein (TRIO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Triple Functional Domain Protein (TRIO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Triple Functional Domain Protein (TRIO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Triple Functional Domain Protein (TRIO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triple Functional Domain Protein (TRIO) ELISA Kit Customized Service Offer