Transcription Factor 7 Like Protein 2 (TCF7L2)

TCF4; HMG box transcription factor 4

TCF7L2 encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes.TCF7L1 and TCF7L2 were not expressed in cells of the lymphoid lineage. The deduced amino acid sequences of the HMG boxes of TCF7L1, TCF7L2, and TCF7 show striking homology. That gene activation by the beta-catenin/TCF4 complex is a critical event in cancer development is indicated by the fact that a subset of colorectal cancers that lack somatic mutations in APC show somatic mutations in the beta-catenin gene. These mutations are presumed to render beta-catenin insensitive to regulation by APC and GSK3B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Polyclonal Antibody Customized Service Offer
Assay Kits SEP601Hu ELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2) ELISA Kit Customized Service Offer