Telethonin (TELE)
TCAP; CMD1N; LGMD2G; T-cap; Titin-cap; 19 kDa Sarcomeric Protein; Limb Girdle Muscular Dystrophy 2G(Autosomal Recessive)
 HGNC 11610
 MGI 1330233
 UniProt O15273
 USCN F894
 Wiki Telethonin
Telethonin (TELE)
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.The C-terminal domain appears to be unstructured in solution. It may promote the assembly of higher order TTN complexes.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a