Telethonin (TELE)
TCAP; CMD1N; LGMD2G; T-cap; Titin-cap; 19 kDa Sarcomeric Protein; Limb Girdle Muscular Dystrophy 2G(Autosomal Recessive)
 HGNC 11610
 MGI 1330233
 PubMed 21799151
 UniProt O15273
 USCN F894
 Wiki Telethonin
Telethonin (TELE)
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.The C-terminal domain appears to be unstructured in solution. It may promote the assembly of higher order TTN complexes.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a