The tachykinin receptor 1 (TACR1) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.Fong et al. (1992) cloned a splice variant of human NK1R that encodes a 311-amino acid protein with a truncated C terminus.

This receptor is considered an attractive drug target, particularly with regards to potential analgesics and anti-depressants. It was identified as a candidate in the etiology of bipolar disorder by a 2008 study. Furthermore TACR1 antagonists have shown promise for the treatment in alcoholism. Finally TACR1 antagonists may also have a role as novel antiemetics.