Tar DNA Binding Protein 43kDa (TDP43)
TARDBP; ALS10
 HGNC 11571
 MGI 2387629
 UniProt Q13148
 USCN B951
 Wiki TARDBP
Tar DNA Binding Protein 43kDa (TDP43)
TAR DNA-binding protein is a cellular factor of 43 kDa that binds specifically to pyrimidine-rich motifs in TAR. Antibody to TDP-43 was used in gel retardation assays to demonstrate that endogenous TDP-43, present in HeLa nuclear extract, also bound to TAR DNA.
Although TDP-43 bound strongly to double-stranded TAR DNA via its ribonucleoprotein protein- binding motifs, it did not bind to TAR RNA extending from 1 to 80. TDP-43 is capable of modulating both in vitro and in vivo HIV-1 gene expression by either altering or blocking the assembly of transcription complexes that are capable of responding to Tat.TDP-43 is the major disease protein in both disorders.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB951Hu01 Recombinant Tar DNA Binding Protein 43kDa (TDP43) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB951Hu22 Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) WB, ICC, IHC-P, IHC-F, ELISA
PAB951Hu01 Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB951Hu ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB951Mu01 Recombinant Tar DNA Binding Protein 43kDa (TDP43) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB951Mu01 Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a