Sphingosine Kinase 1 (SPHK1)
 HGNC 11240
 MGI 1316649
 PubMed 16980623
 RGD 620048
 UniProt Q9NYA1
 USCN E698
 Wiki SPHK1
Sphingosine Kinase 1 (SPHK1)
Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.Sequence comparisons of the mammalian SPHK proteins and SPHKs from other organisms identified 5 regions that are highly conserved. Northern blot analysis of mouse adult tissues showed ubiquitous expression of Sphk1, with the highest levels found in lung and spleen.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE698Hu01 Recombinant Sphingosine Kinase 1 (SPHK1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAE698Hu21 Monoclonal Antibody to Sphingosine Kinase 1 (SPHK1) WB, ICC, IHC-P, IHC-F, ELISA
PAE698Hu01 Polyclonal Antibody to Sphingosine Kinase 1 (SPHK1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEE698Hu ELISA Kit for Sphingosine Kinase 1 (SPHK1) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a