Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)
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LST1; OATPC; OATP1B1; OATP2; SLC21A6; Solute Carrier 21 Member 6; Sodium-independent organic anion-transporting polypeptide 2; Liver-specific organic anion transporter 1
 HGNC 10959
 PubMed 18650507
 UniProt Q9Y6L6
 USCN E517
 Wiki SLCO1B1
Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1)
SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. The SLC21A6 gene encodes a deduced 691-amino acid protein containing 12 transmembrane domains, 7 putative N-glycosylation sites in the extracellular loops, and 2 potential phosphorylation sites. Northern blot analysis detected major 3.0- and minor 4.8-kb SLC21A6 transcripts exclusively in liver, in contrast to the more widely expressed SLC21A3.
Organism species: Homo sapiens (Human)
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a