Sex Determining Region Y Box Protein 2 (SOX2)
ANOP3; MCOPS3; SRY-Box 2
 HGNC 11195
 MGI 98364
 OMIM 184429
 RGD 1565646
 UCSC uc003fkx.2
 UniProt P48431
 USCN 90406
Sex Determining Region Y Box Protein 2 (SOX2)
Sox2 is one of the key transcription factors required in induced pluripotent stem cells. As forced Oct4 expression induces pluripotency in Sox2-null cells, a group of researchers concluded that the primary role of Sox2 in induced pluripotent stem cells is controlling Oct4 expression, and they perpetuate their own expression when expressed concurrently.The protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).The ectopic expression of SOX2 may be related to abnormal differentiation of colorectal cancer cells.
 ELISA Kits(Enzyme-linked immunosorbent assay Kits)
Catalog Product Name Organism Manual
E90406HuELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2)Homo sapiens (Human)  n/a
E90406MuELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2)Mus musculus (Mouse)  n/a
E90406RaELISA Kit for Sex Determining Region Y Box Protein 2 (SOX2)Rattus norvegicus (Rat)  PDF
 CLIA Kits(Chemiluminescent immunoassay Kits)
Catalog Product Name Organism Manual
C90406HuCLIA Kit for Sex Determining Region Y Box Protein 2 (SOX2)Homo sapiens (Human)  n/a
C90406MuCLIA Kit for Sex Determining Region Y Box Protein 2 (SOX2)Mus musculus (Mouse)  n/a
C90406RaCLIA Kit for Sex Determining Region Y Box Protein 2 (SOX2)Rattus norvegicus (Rat)  n/a