Serine/Threonine Kinase 11 (STK11)
LKB1; PJS; Polarization-Related Protein LKB1; Peutz-Jeghers Syndrome
 HGNC 11389
 MGI 1341870
 PubMed 22698401
 RGD 1308653
 UniProt Q15831
 USCN H115
 Wiki STK11
Serine/Threonine Kinase 11 (STK11)
LKB1 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It is now clear that LKB1 exerts its growth suppressing effects by activating a group of other ~14 kinases, comprising AMPK and AMPK-related kinases. Activation of AMPK by LKB1 suppresses growth and proliferation when energy and nutrient levels are scarce. Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH115Mu01 Recombinant Serine/Threonine Kinase 11 (STK11) SDS-PAGE; WB; ELISA; IP.
RPH115Mu02 Recombinant Serine/Threonine Kinase 11 (STK11) SDS-PAGE; WB; ELISA; IP.
Antibodies PAH115Mu01 Polyclonal Antibody to Serine/Threonine Kinase 11 (STK11) IWB, ICC, IHC-P, IHC-F, ELISA
PAH115Mu02 Polyclonal Antibody to Serine/Threonine Kinase 11 (STK11) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEH115Mu ELISA Kit for Serine/Threonine Kinase 11 (STK11) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a