S100 Calcium Binding Protein A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100C may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.By in situ hybridization, Moog-Lutz et al. mapped the calgizzarin, or S100C, gene to 1q21. By analysis of clones from this region, Wicki et al. determined that S100A11 is part of the S100 gene cluster and is located near S100A10