Retinoic Acid And Interferon Inducible Protein 58kDa (RI58)
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IFIT5; ISG58; P58; Interferon-induced 58 kDa protein; Interferon-Induced Protein With Tetratricopeptide Repeats 5
 HGNC 13328
 UniProt Q13325
 USCN Q379
Retinoic Acid And Interferon Inducible Protein 58kDa (RI58)
RI58, was isolated from a cDNA library constructed from retinoic acid-treated NB4 cells by differential hybridization. RI58 cDNA encodes a protein of 58kDa which has a similarity in its amino acids sequence to interferon (IFN)-inducible proteins. In addition, RI58 was induced by recombinant human IFN-alpha (rhIFN-alpha) in NB4 cells. RI58 was detectable within 4 hours post-stimulation with rhIFN-alpha, while it took as long as 1day after retinoic acid stimulation. Culture supernatant from retinoic acid-treated NB4 cells also induced RI58 expression similarly as rhIFN-alpha. This activity in culture supernatant was inhibited by anti-leukocyte IFN antiserum which showed specific reactivity to rhIFN-alpha. These results indicate that RI58 is induced by retinoic acid stimulation through autocrinally secreted IFN-alpha from NB4 cells. In the retinoic acid-treated NB4 cells, the expression of RI58 was increased along the process of differentiation.
Organism species: Homo sapiens (Human)
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