Retinitis Pigmentosa GTPase Regulator (RPGR)
CRD; COD1; CORDX1; PCDX; RP15; RP3; XLRP3; Orf15; Retinitis Pigmentosa 15; Cone Dystrophy 1(X-Linked)
 HGNC 10295
 MGI 1344037
 UniProt Q92834
 USCN F777
 Wiki RPGR
Retinitis Pigmentosa GTPase Regulator (RPGR)
RPGR encodes a protein with a series of six RCC1-like domains, characteristic of the highly conserved guanine nucleotide exchange factors. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.The predicted 90-kD RPGR protein contains in its N-terminal half a tandem repeat structure highly similar to the regulator of chromosome condensation (RCC1), which regulates the GTPase RAN. The C terminus of the protein contains a cluster of basic residues followed by a consensus isoprenylation site. The authors noted that confirmation of the isoprenylation of this site would establish a novel means of membrane anchorage for a GTPase regulator.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a