Prothrombin Fragment 1+2(F1+2)
Prothrombin is a carbohydrate-protein compound in plasma essential to coagulation. In response to bleeding, a complex series of clotting-factor interactions leads to its conversion by thromboplastin to thrombin, which transforms fibrinogen in plasma into fibrin. Fibrin and platelets combine to form a clot. Hemophilia is caused by a hereditary lack of one of the clotting factors. Vitamin K is needed to synthesize prothrombin, so conditions that impair the vitamin's absorption result in prothrombin deficiency and a tendency to prolonged bleeding.
Prothrombin and
prothrombin fragment F1+2 (F1+2) were demonstrated in the tumor stroma on cancer cells and on small blood vessels in areas of neoangiogenesis at the host-tumor interface (gastric and pancreatic cancer tissues). F1+2 is an indicator of local activation of blood coagulation in cancer tissue.
Thrombin itself is impossible to quantitate and so the use of surrogate markers is necessary. The measurement of F1+2 would be an excellent marker of thrombin generation. This is helped by the fact that F1+2 is not generated in vivo by any other mechanism. Fragment 1+2 has a half life of about 1 hour and is cleared from the bloodstream by the liver.
ELISA Kits(Enzyme-linked immunosorbent assay Kits)
Antibodies
CLIA Kits(Chemiluminescent immunoassay Kits)
| Catalog |
Product Name |
Species |
Packing |
Price |
Manual |
| C90710Hu | CLIA Kit for Human Prothrombin Fragment 1+2(F1+2) | Human | n/a | n/a | n/a |
| C90710Mu | CLIA Kit for Mouse Prothrombin Fragment 1+2(F1+2) | Mouse | n/a | n/a | n/a |
| C90710Ra | CLIA Kit for Rat Prothrombin Fragment 1+2(F1+2) | Rat | n/a | n/a | n/a |
| C90710Rb | CLIA Kit for Rabbit Prothrombin Fragment 1+2(F1+2) | Rabbit | n/a | n/a | n/a |
| C90710Po | CLIA Kit for Porcine Prothrombin Fragment 1+2(F1+2) | Pig | n/a | n/a | n/a |