Protein Kinase R (PKR)
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PRKR; PRK-R; EIF2AK2; EIF2AK1; Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2; Interferon-induced, double-stranded RNA-activated protein kinase; P1/eIF-2A kinase
 HGNC 9437
 MGI 1353449
 PubMed 17969452
 RGD 3402
 UniProt P19525
 USCN A520
 Wiki PKR
Protein Kinase R (PKR)
PKR is activated by double-stranded RNA (dsRNA), the synthesis of which is caused virally. PKR can also be activated by the protein PACT or by heparin. PKR contains an N-terminal dsRNA binding domain (dsRBD) and a C-terminal kinase domain, that gives it pro-apoptotic (cell-killing) functions. The dsRBD consists of two tandem copies of a conserved double stranded RNA binding motif, dsRBM1 and dsRBM2. PKR is induced by interferon in a latent state. Binding to dsRNA is believed to activate PKR by inducing dimerization and subsequent autophosphorylation reactions. In situations of viral infection, the dsRNA created by viral replication and gene expression binds to the N-terminal domain, activating the protein and causing apoptosis of the cell to prevent further viral spread.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA520Hu01 Recombinant Protein Kinase R (PKR) SDS-PAGE; WB; ELISA; IP.
Antibodies MAA520Hu22 Monoclonal Antibody to Protein Kinase R (PKR) WB, ICC, IHC-P, IHC-F, ELISA
PAA520Hu01 Polyclonal Antibody to Protein Kinase R (PKR) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEA520Hu ELISA Kit for Protein Kinase R (PKR) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA520Mu01 Recombinant Protein Kinase R (PKR) SDS-PAGE; WB; ELISA; IP.
Antibodies PAA520Mu01 Polyclonal Antibody to Protein Kinase R (PKR) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA520Ra01 Recombinant Protein Kinase R (PKR) SDS-PAGE; WB; ELISA; IP.
Antibodies PAA520Ra01 Polyclonal Antibody to Protein Kinase R (PKR) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a