Prostaglandin E2 receptor (53kDa), also known as EP₂, is a prostaglandin receptor for prostaglandin E2.The receptor is a G-protein coupled receptor, which activates the G protein G_s.

Prostaglandin E2 (PGE2), one of various oxygenated metabolites of arachidonic acid, produces a broad range of biologic actions in diverse tissues. Not only are PGE2 and thromboxane A2 structurally related, but their receptors are also homologous. Taketo et al. (1994) cloned mouse cDNA sequences for PGE2 receptor subtypes EP2 (PTGER2) and EP3 (PTGER3).Prostanoid receptors of the EP1, EP2, EP3, and EP4 types cloned in the mouse and/or human were reviewed by Coleman et al. (1994).