Prostaglandin E1 (PGE1)
(PGE1) is pharmaceutically known as Alprostadil. It is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties.Alprostadil is sold in the United States as urethral suppositories, under the brand name MUSE (Medicated Urethral Suppository for Erection) by Vivus. It is also sold in injectable form as Caverject and Edex.
Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection will be needed. Caverject and Edex are similarly fast-acting, but are actually injected directly into the corpus cavernosum of the penis.It is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and the alprostadil is sometimes difficult to get. There are different formulations (bi-mix, trimix) which may include papaverine and/or phentolamine. A sample mix might be papaverine 30 mg, phentolamine 2 mg, & alprostadil 20 mcg