Promyelocytic Leukemia Protein (PML)
MYL; RNF71; TRIM19; Probable Transcription Factor PML; Ring Finger Protein 71
 HGNC 9113
 MGI 104662
 RGD 1562602
 UniProt P29590
 USCN C221
Promyelocytic Leukemia Protein (PML)
Probable transcription factor PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies (Nuclear dots) where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC221Hu01 Recombinant Promyelocytic Leukemia Protein (PML) SDS-PAGE; WB; ELISA; IP.
Antibodies MAC221Hu22 Monoclonal Antibody to Promyelocytic Leukemia Protein (PML) WB, ICC, IHC-P, IHC-F, ELISA
PAC221Hu01 Polyclonal Antibody to Promyelocytic Leukemia Protein (PML) WB, ICC, IHC-P, IHC-F, ELISA
PAC221Hu71 Biotin-Linked Antibody to Promyelocytic Leukemia Protein (PML) IHC;WB;ELISA
PAC221Hu81 FITC-Linked Antibody to Promyelocytic Leukemia Protein (PML) IHC;ICC;IF;WB
Assay Kits SEC221Hu ELISA Kit for Promyelocytic Leukemia Protein (PML) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a