Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2)
[ Edit ]
CD273; B7DC; Btdc; PD-L2; PDCD1-L2; PDL2
 HGNC 18731
 MGI 1930125
 PubMed 24664538
 RGD 1306403
 UniProt Q9BQ51
 USCN A789
 Wiki PDCD1LG2
Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2)
Using flow cytometric analysis, Latchman et al. (2001) showed that the IgV region of mouse Pdl2, like Pdl1, binds to human PDCD1 but not to CTLA4, CD28 , or ICOS. Stimulation of mouse T cells with anti-CD3 and Pdl2 or Pdl1 resulted in inhibition of proliferation and cytokine production, and Pdl2 could inhibit T-cell receptor -CD28 signals at low antigen concentrations. Latchman et al. (2001) proposed that blocking of the PDL-PDCD1 pathway may enhance antitumor immunity, whereas stimulating this pathway may help downregulate graft rejection and autoimmune and allergic reactions.
Latchman et al. (2001) mapped the PDL2 gene to chromosome 9p24.2, in close proximity to the PDL1 gene. Tseng et al. (2001) mapped the mouse Pdl2 gene to chromosome 19C2-C3.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA789Hu01 Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) SDS-PAGE; WB; ELISA; IP.
Antibodies MAA789Hu21 Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) WB, ICC, IHC-P, IHC-F, ELISA
PAA789Hu01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEA789Hu ELISA Kit for Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA789Ra01 Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) SDS-PAGE; WB; ELISA; IP.
Antibodies PAA789Ra01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a