Prickle Homolog 1 (PRICKLE1)
EPM1B; RILP; REST/NRSF-interacting LIM domain protein 1
PRICKLE1 encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. The deduced 831-amino acid protein contains 3 N-terminal LIM domains and 3 C-terminal nuclear localization signals. It also contains 4 N-glycosylation sites, 2 PKA phosphorylation sites, and a C-terminal CIIS (cys-ile-ile-ser) prenylation motif. Northern blot analysis detected a single 4.4-kb transcript in all tissues examined, with the highest level in placenta.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Prickle Homolog 1 (PRICKLE1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Prickle Homolog 1 (PRICKLE1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Prickle Homolog 1 (PRICKLE1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Prickle Homolog 1 (PRICKLE1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Prickle Homolog 1 (PRICKLE1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Prickle Homolog 1 (PRICKLE1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Prickle Homolog 1 (PRICKLE1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Prickle Homolog 1 (PRICKLE1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Prickle Homolog 1 (PRICKLE1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Prickle Homolog 1 (PRICKLE1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Prickle Homolog 1 (PRICKLE1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Prickle Homolog 1 (PRICKLE1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Prickle Homolog 1 (PRICKLE1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Prickle Homolog 1 (PRICKLE1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Prickle Homolog 1 (PRICKLE1) | ELISA Kit Customized Service Offer |