Presenilin 2 (PS2)
PSEN2; AD3L; AD4; PS2; STM2; AD3LP; AD5; Alzheimer Disease 4
Presenilin-2is a protein that is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. In melanocytic cells PSEN2 gene expression may be regulated by MITF.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Presenilin 2 (PS2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Presenilin 2 (PS2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Presenilin 2 (PS2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Presenilin 2 (PS2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Presenilin 2 (PS2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Presenilin 2 (PS2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Presenilin 2 (PS2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Presenilin 2 (PS2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Presenilin 2 (PS2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Presenilin 2 (PS2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB274Ra01 | Recombinant Presenilin 2 (PS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB274Ra01 | Polyclonal Antibody to Presenilin 2 (PS2) | WB; IHC; ICC; IP. |
MAB274Ra21 | Monoclonal Antibody to Presenilin 2 (PS2) | WB; IHC; ICC; IP. | |
Assay Kits | SEB274Ra | ELISA Kit for Presenilin 2 (PS2) | Enzyme-linked immunosorbent assay for Antigen Detection. |