Presenilin 2 (PS2)
[ Edit ]
PSEN2; AD3L; AD4; PS2; STM2; Alzheimer Disease 4
 HGNC 9509
 MGI 109284
 PubMed 8817335
 RGD 621060
 UniProt P49810
 USCN B274
 Wiki Presenilin_2
Presenilin 2 (PS2)
Presenilin-2 is a protein that is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. In melanocytic cells PSEN2 gene expression may be regulated by MITF.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB274Ra01 Recombinant Presenilin 2 (PS2) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB274Ra21 Monoclonal Antibody to Presenilin 2 (PS2) WB, ICC, IHC-P, IHC-F, ELISA
PAB274Ra01 Polyclonal Antibody to Presenilin 2 (PS2) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB274Ra ELISA Kit for Presenilin 2 (PS2) Enzyme-linked immunosorbent assay