Post GPI Attachment To Proteins 2 (PGAP2)
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FRAG1; CWH43-N; FGF Receptor Activating Protein 1; Cell Wall Biogenesis 43 N-Terminal Homolog
 HGNC 17893
 MGI 2385286
 PubMed 23561847
 RGD 619744
 UniProt Q9UHJ9
 USCN Q630
Post GPI Attachment To Proteins 2 (PGAP2)
Biosynthesis of glycosylphosphatidylinositol-anchored proteins in the ER has been extensively studied, whereas the molecular events during the transport of GPI-APs from the ER to the cell surface are poorly understood. PGAP2 encoded a Golgi/ER-resident membrane protein. The low surface expression of GPI-APs was due to their secretion into the culture medium. GPI-APs were modified/cleaved by two reaction steps in the mutant cells. First, the GPI anchor was converted to lyso-GPI before exiting the trans-Golgi network. Second, lyso-GPI-APs were cleaved by a phospholipase D after transport to the plasma membrane.PGAP2 deficiency caused transport to the cell surface of lyso-GPI-APs that were sensitive to a phospholipase D. PGAP2 is involved in the processing of GPI-APs required for their stable expression at the cell surface.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a