Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)
PPAPDC2; Phosphatidic Acid Phosphatase Type 2 Domain Containing 2
 HGNC 23682
 MGI 1921661
 RGD 1566000
 UniProt Q8IY26
 USCN N400
Polyisoprenoid Diphosphate Phosphatase Type 1 (PDP1)
PPAPDC2 contains 6 predicted membrane-spanning domains and 3 conserved lipid phosphate phosphatase motifs. RT-PCR detected expression in both human polymorphonuclear leukocytes and HEK293 cells. Dot-blot analysis of human tissues detected strong expression in pancreas, placenta, spleen, liver, kidney, colon, pituitary gland, and thymus, and moderate to low expression in duodenum, whole brain, stomach, esophagus, lung, testis, and heart. Semiquantitative RT-PCR detected PPAPDC2 expression in PMN leukocytes at 60% of levels in liver.PPAPDC2 activity was optimal at pH 7.0 and 8.0 and was independent of divalent cations. Thin-layer chromatography using C14-labeled substrates showed that PPAPDC2 catalyzed dephosphorylation of PSDP to presqualene monophosphate but not PSMP to presqualene alcohol.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a