Phospholamban (PLN)

PLB; CMD1P; Cardiac phospholamban

Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2 pump in cardiac muscle and skeletal muscle cells. When phospholamban is phosphorylated by protein kinase A (PKA) its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation) may enhance the rate of cardiac myocyte relaxation.

Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB884Hu01 Recombinant Phospholamban (PLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB884Hu01 Polyclonal Antibody to Phospholamban (PLN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholamban (PLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholamban (PLN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB884Mu01 Recombinant Phospholamban (PLN) Positive Control; Immunogen; SDS-PAGE; WB.
RPB884Mu02 Recombinant Phospholamban (PLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB884Mu01 Polyclonal Antibody to Phospholamban (PLN) WB; IHC; ICC; IP.
PAB884Mu02 Polyclonal Antibody to Phospholamban (PLN) WB; IHC; ICC; IP.
Assay Kits SEB884Mu ELISA Kit for Phospholamban (PLN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholamban (PLN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholamban (PLN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholamban (PLN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholamban (PLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholamban (PLN) ELISA Kit Customized Service Offer