Phospholamban (PLN)
PLB; CMD1P
 HGNC 9080
 MGI 97622
 PubMed 12838339
 RGD 619894
 UniProt P26678
 USCN B884
 Wiki PLN
Phospholamban (PLN)
Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2 pump in cardiac muscle and skeletal muscle cells. When phospholamban is phosphorylated by protein kinase A (PKA) its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation) may enhance the rate of cardiac myocyte relaxation.
Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB884Hu01 Recombinant Phospholamban (PLN) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB884Hu01 Polyclonal Antibody to Phospholamban (PLN) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB884Mu01 Recombinant Phospholamban (PLN) SDS-PAGE; WB; ELISA; IP.
RPB884Mu02 Recombinant Phospholamban (PLN) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB884Mu01 Polyclonal Antibody to Phospholamban (PLN) WB, ICC, IHC-P, IHC-F, ELISA
PAB884Mu02 Polyclonal Antibody to Phospholamban (PLN) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB884Mu ELISA Kit for Phospholamban (PLN) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a