Phosphoinositide Dependent Protein Kinase 1 (PDPK1)
PDK1; PkB-Like 1
 HGNC 8816
 MGI 1338068
 PubMed 22952425
 RGD 620307
 UniProt O15530
 USCN C246
 Wiki PDPK1
Phosphoinositide Dependent Protein Kinase 1 (PDPK1)
PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signalling. Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals nescessary for normal mammalian development.
Mice that are deficient in PDPK1 have a ≈40% decrease in body mass, mild glucose intolerance, and are resitant to cancer brought about by hyperactivation of the PI3K pathway (PTEN +/-).The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the PH domain.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC246Hu01 Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC246Hu01 Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC246Mu01 Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) SDS-PAGE; WB; ELISA; IP.
RPC246Mu02 Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC246Mu01 Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) WB, ICC, IHC-P, IHC-F, ELISA
PAC246Mu02 Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC246Mu ELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a