Phosphofructokinase, Muscle (PFKM)
PFK1; PFKX; Phosphofructokinase 1; Phosphofructo-1-kinase isozyme A; 6-Phosphofructokinase Polypeptide X; Fructose-6-Phosphate 1-Phosphotransferase
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Phosphofructokinase-1 (PFK-1) is the most important regulatory enzyme (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors. PFK-1 catalyzes one of the important "committed" steps of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP.
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PFK1 is allosterically inhibited by ATP and citrate (from the citric acid cycle) and its product. It is also inhibited by low pH to prevent the accumulation of hydrogen ions in muscle. The enzyme has two sites with different affinities for ATP which is both a substrate and an inhibitor.PFK1 is allosterically activated by a high concentration of AMP, but the most potent activator is fructose 2,6-bisphosphate, which is also produced from fructose-6-phosphate by PFK2.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD405Hu01 | Recombinant Phosphofructokinase, Muscle (PFKM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD405Hu01 | Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) | WB; IHC; ICC; IP. |
MAD405Hu21 | Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) | WB; IHC; ICC; IP. | |
Assay Kits | SED405Hu | ELISA Kit for Phosphofructokinase, Muscle (PFKM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Phosphofructokinase, Muscle (PFKM) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Phosphofructokinase, Muscle (PFKM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Phosphofructokinase, Muscle (PFKM) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD405Ra01 | Recombinant Phosphofructokinase, Muscle (PFKM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD405Ra01 | Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) | WB; IHC; ICC; IP. |
MAD405Ra21 | Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) | WB; IHC; ICC; IP. | |
Assay Kits | SED405Ra | ELISA Kit for Phosphofructokinase, Muscle (PFKM) | Enzyme-linked immunosorbent assay for Antigen Detection. |