Phosphofructokinase, Muscle (PFKM)
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PFK1; PFKX; Phosphofructokinase 1; Phosphofructo-1-kinase isozyme A; 6-Phosphofructokinase Polypeptide X; Fructose-6-Phosphate 1-Phosphotransferase
 HGNC 8877
 MGI 97548
 PubMed 6213050
 RGD 68419
 UniProt P08237
 USCN D405
 Wiki PFKM
Phosphofructokinase, Muscle (PFKM)
Phosphofructokinase-1 (PFK-1) is the most important regulatory enzyme (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors. PFK-1 catalyzes one of the important "committed" steps of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP.
PFK1 is allosterically inhibited by ATP and citrate (from the citric acid cycle) and its product. It is also inhibited by low pH to prevent the accumulation of hydrogen ions in muscle. The enzyme has two sites with different affinities for ATP which is both a substrate and an inhibitor.PFK1 is allosterically activated by a high concentration of AMP, but the most potent activator is fructose 2,6-bisphosphate, which is also produced from fructose-6-phosphate by PFK2.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD405Hu01 Recombinant Phosphofructokinase, Muscle (PFKM) SDS-PAGE; WB; ELISA; IP.
Antibodies MAD405Hu21 Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB, ICC, IHC-P, IHC-F, ELISA
PAD405Hu01 Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SED405Hu ELISA Kit for Phosphofructokinase, Muscle (PFKM) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD405Ra01 Recombinant Phosphofructokinase, Muscle (PFKM) SDS-PAGE; WB; ELISA; IP.
Antibodies MAD405Ra21 Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB, ICC, IHC-P, IHC-F, ELISA
PAD405Ra01 Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SED405Ra ELISA Kit for Phosphofructokinase, Muscle (PFKM) Enzyme-linked immunosorbent assay