Phosphodiesterase 6A, cGMP Specific (PDE6A)
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 HGNC 8785
 MGI 97524
 PubMed 20940301
 RGD 1306835
 UniProt P16499
 USCN F646
 Wiki PDE6A
Phosphodiesterase 6A, cGMP Specific (PDE6A)
PDE6A encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. the human PDEA gene consists of 22 exons spanning approximately 45 to 50 kb.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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