Phosphodiesterase 4D Interacting Protein (PDE4DIP)
CMYA2; MMGL; Myomegalin; Cardiomyopathy Associated 2
 HGNC 15580
 MGI 1891434
 PubMed 11134006
 RGD 708410
 UniProt Q5VU43
 USCN F659
 Wiki PDE4DIP
Phosphodiesterase 4D Interacting Protein (PDE4DIP)
By analyzing ESTs for cardiac muscle-specific transcripts, followed by screening heart cDNA libraries and 5-prime RACE, Soejima et al. (2001) cloned 4 splice variants of PDE4DIP, which they called MMGL. The variant-1 transcript has a long 3-prime untranslated region containing 9 possible polyadenylation signals, and it encodes a deduced 174-amino acid protein. Variants 2, 3, and 4 encode proteins of 174, 173, and 240 amino acids, respectively. Northern blot analysis detected high expression of a 1.0- to 1.3-kb band and lower expression of 4.4- and 8.5-kb bands in adult and fetal heart, skeletal muscle, and all specific heart regions examined. Only the 4.4-kb transcript was detected in aorta. Fluorescence-tagged variants 1 and 4 were expressed in both the cytoplasm and nucleus of transfected mouse myocytes.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
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Assay Kits n/a n/a n/a