Phosphatase And Tensin Homolog (PTEN)
BZS; MHAM; MMAC1; PTEN1; TEP1; Mutated In Multiple Advanced Cancers 1
 HGNC 9588
 MGI 109583
 PubMed 23212910
 RGD 61995
 UniProt P60484
 USCN F822
 Wiki PTEN
Phosphatase And Tensin Homolog (PTEN)
PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly.This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF822Hu01 Recombinant Phosphatase And Tensin Homolog (PTEN) SDS-PAGE; WB; ELISA; IP.
Antibodies MAF822Hu21 Monoclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB, ICC, IHC-P, IHC-F, ELISA
PAF822Hu01 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB, ICC, IHC-P, IHC-F, ELISA
PAF822Hu71 Biotin-Linked Antibody to Phosphatase And Tensin Homolog (PTEN) IHC;WB;ELISA
Assay Kits SEF822Hu ELISA Kit for Phosphatase And Tensin Homolog (PTEN) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF822Mu01 Recombinant Phosphatase And Tensin Homolog (PTEN) SDS-PAGE; WB; ELISA; IP.
RPF822Mu02 Recombinant Phosphatase And Tensin Homolog (PTEN) SDS-PAGE; WB; ELISA; IP.
Antibodies PAF822Mu01 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) IWB, ICC, IHC-P, IHC-F, ELISA
PAF822Mu02 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEF822Mu ELISA Kit for Phosphatase And Tensin Homolog (PTEN) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF822Ra01 Recombinant Phosphatase And Tensin Homolog (PTEN) SDS-PAGE; WB; ELISA; IP.
Antibodies MAF822Ra21 Monoclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB, ICC, IHC-P, IHC-F, ELISA
PAF822Ra01 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEF822Ra ELISA Kit for Phosphatase And Tensin Homolog (PTEN) Enzyme-linked immunosorbent assay