Perforin 1 (PRF1)
[ Edit ]
FLH2; HPLH2; P1; PFP; Pore Forming Protein; Cytolysin; Lymphocyte pore-forming protein
 HGNC 9360
 MGI 97551
 PubMed 2783486
 RGD 708463
 UniProt P14222
 USCN B317
 Wiki PRF1
Perforin 1 (PRF1)
Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Perforin is a cytolytic protein found in the granules of Cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB317Hu01 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB317Hu22 Monoclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Hu01 Polyclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Hu71 Biotin-Linked Antibody to Perforin 1 (PRF1) IHC;WB;ELISA
PAB317Hu81 FITC-Linked Antibody to Perforin 1 (PRF1) IHC;ICC;IF;WB
Assay Kits SEB317Hu ELISA Kit for Perforin 1 (PRF1) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB317Mu01 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
RPB317Mu02 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB317Mu01 Polyclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Mu02 Polyclonal Antibody to Perforin 1 (PRF1) IWB, ICC, IHC-P, IHC-F, ELISA
PAB317Mu71 Biotin-Linked Antibody to Perforin 1 (PRF1) IHC;WB;ELISA
PAB317Mu81 FITC-Linked Antibody to Perforin 1 (PRF1) IHC;ICC;IF;WB
Assay Kits SEB317Mu ELISA Kit for Perforin 1 (PRF1) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB317Ra01 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB317Ra21 Monoclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Ra01 Polyclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB317Ra ELISA Kit for Perforin 1 (PRF1) Enzyme-linked immunosorbent assay