Perforin 1 (PRF1)
FLH2; HPLH2; P1; PFP; Pore Forming Protein
 HGNC 9360
 MGI 97551
 RGD 708463
 UniProt P14222
 USCN B317
Perforin 1 (PRF1)
Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane inserting part of perforin is the MACPF domain. This region shares homology with cholesterol dependent cytolysins from Gram positive bacteria.
Although purified perforin is sufficient to lyse cells at high doses, the biology of perforin itself does not explain the ability of CD8 T-cells and NK cells to induce apoptosis in target cells. This induction of apoptosis may require at least one other granule protein, granzyme B.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB317Hu01 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB317Hu22 Monoclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Hu01 Polyclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Hu71 Biotin-Linked Antibody to Perforin 1 (PRF1) IHC;WB;ELISA
PAB317Hu81 FITC-Linked Antibody to Perforin 1 (PRF1) IHC;ICC;IF;WB
Assay Kits SEB317Hu ELISA Kit for Perforin 1 (PRF1) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB317Mu01 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
RPB317Mu02 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB317Mu01 Polyclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Mu02 Polyclonal Antibody to Perforin 1 (PRF1) IWB, ICC, IHC-P, IHC-F, ELISA
PAB317Mu71 Biotin-Linked Antibody to Perforin 1 (PRF1) IHC;WB;ELISA
PAB317Mu81 FITC-Linked Antibody to Perforin 1 (PRF1) IHC;ICC;IF;WB
Assay Kits SEB317Mu ELISA Kit for Perforin 1 (PRF1) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB317Ra01 Recombinant Perforin 1 (PRF1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB317Ra21 Monoclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
PAB317Ra01 Polyclonal Antibody to Perforin 1 (PRF1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB317Ra ELISA Kit for Perforin 1 (PRF1) Enzyme-linked immunosorbent assay