POU Domain Class 6 Transcription Factor 1 (POU6F1)
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BRN5; MPOU; TCFB1
 HGNC 9224
 MGI 102935
 PubMed 20134265
 RGD 620615
 UniProt Q14863
 USCN Q309
POU Domain Class 6 Transcription Factor 1 (POU6F1)
Expression of POU6F1 at messenger RNA and protein was confirmed in cell lines derived from epithelial ovarian carcinoma. The microarray analyses performed using the 2 ovarian cancer microarray data sets available on the Internet indicated that POU6F1 expression was significantly greater in clear cell adenocarcinoma. Immunostaining confirmed the nuclear localization of POU6F1 in clear cell adenocarcinoma (100%).
Exposure to the siRNA for POU6F1 reduced the expression of lysophosphatidic acid receptors, which are G protein-coupled receptors involved in tumor cell proliferation. POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines, and a similar effect was confirmed for tumors transplanted into nude mice.
Organism species: Homo sapiens (Human)
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Antibodies n/a n/a n/a
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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Proteins n/a n/a n/a
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