Purine Nucleoside Phosphorylase (PNP)
NP; PUNP; Nucleoside Phosphorylase; Inosine phosphorylase; Inosine-guanosine phosphorylase
NP encodes the enzyme purine nucleoside phosphorylase that together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in either enzyme result in a severe combined immunodeficiency (SCID).
Nucleoside phosphorylase is an enzyme which, as its name implies, phosphorylates a nucleoside to produce a nucleotide monophosphate. It is one enzyme of the nucleotide salvage pathways. These pathways allow the cell to produce nucleotide monophosphates when the de novo synthesis pathway has been interrupted or is non-existent (as is the case in the brain). Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC683Hu01 | Recombinant Purine Nucleoside Phosphorylase (PNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC683Hu01 | Polyclonal Antibody to Purine Nucleoside Phosphorylase (PNP) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Purine Nucleoside Phosphorylase (PNP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Purine Nucleoside Phosphorylase (PNP) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC683Mu01 | Recombinant Purine Nucleoside Phosphorylase (PNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC683Mu01 | Polyclonal Antibody to Purine Nucleoside Phosphorylase (PNP) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Purine Nucleoside Phosphorylase (PNP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Purine Nucleoside Phosphorylase (PNP) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC683Ra01 | Recombinant Purine Nucleoside Phosphorylase (PNP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC683Ra01 | Polyclonal Antibody to Purine Nucleoside Phosphorylase (PNP) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Purine Nucleoside Phosphorylase (PNP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Purine Nucleoside Phosphorylase (PNP) | ELISA Kit Customized Service Offer |