Notch Homolog 3 (NOTCH3)
CADASIL; CASIL; Neurogenic locus notch homolog protein 3
NOTCH3 encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development.
Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL147Hu01 | Recombinant Notch Homolog 3 (NOTCH3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAL147Hu01 | Polyclonal Antibody to Notch Homolog 3 (NOTCH3) | WB; IHC; ICC; IP. |
Assay Kits | SEL147Hu | ELISA Kit for Notch Homolog 3 (NOTCH3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPL147Mu01 | Recombinant Notch Homolog 3 (NOTCH3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAL147Mu01 | Polyclonal Antibody to Notch Homolog 3 (NOTCH3) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Notch Homolog 3 (NOTCH3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Notch Homolog 3 (NOTCH3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Notch Homolog 3 (NOTCH3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Notch Homolog 3 (NOTCH3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Notch Homolog 3 (NOTCH3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Notch Homolog 3 (NOTCH3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Notch Homolog 3 (NOTCH3) | ELISA Kit Customized Service Offer |