Noggin (NOG)
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SYM1; SYNS1; Synostoses(Multiple)Syndrome 1; Symphalangism 1(Proximal)
 HGNC 7866
 MGI 104327
 PubMed 11163261
 RGD 3183
 UniProt Q13253
 USCN C130
 Wiki Noggin
Noggin (NOG)
Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming TGF-beta superfamily signaling proteins, such as BMP4. By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Hu01 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
RPC130Hu02 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
Antibodies MAC130Hu22 Monoclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Hu01 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Hu02 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Hu71 Biotin-Linked Antibody to Noggin (NOG) IHC;WB;ELISA
PAC130Hu81 FITC-Linked Antibody to Noggin (NOG) IHC;ICC;IF;WB
Assay Kits SEC130Hu ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Mu01 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
RPC130Mu02 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC130Mu01 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Mu02 Polyclonal Antibody to Noggin (NOG) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC130Mu ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Ra01 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
RPC130Ra02 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
RPC130Ra03 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
RPC130Ra04 Recombinant Noggin (NOG) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC130Ra01 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Ra02 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Ra03 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
PAC130Ra04 Polyclonal Antibody to Noggin (NOG) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC130Ra ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay