Noggin (NOG)
SYM1; SYNS1; Synostoses(Multiple)Syndrome 1; Symphalangism 1(Proximal)
Noggin inhibits TGF-beta signal transduction by binding to TGF-beta family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming TGF-beta superfamily signaling proteins, such as BMP4. By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC130Hu01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC130Hu02 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APC130Hu01 | Active Noggin (NOG) | Cell culture; Activity Assays. | |
EPC130Hu61 | Eukaryotic Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC130Hu01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
MAC130Hu22 | Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
PAC130Hu02 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
LAC130Hu71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
LAC130Hu81 | FITC-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IF. | |
MAC130Hu24 | Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
MAC130Hu26 | Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
LAC130Hu76 | Biotin-Linked Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
MAC130Hu21 | Monoclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
Assay Kits | SEC130Mi | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
HEC130Mi | High Sensitive ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
SEC130Hu | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC130Mu01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC130Mu02 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC130Mu01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
PAC130Mu02 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
Assay Kits | SEC130Mi | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
HEC130Mi | High Sensitive ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
SEC130Mu | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC130Ra01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC130Ra02 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APC130Ra01 | Active Noggin (NOG) | Cell culture; Activity Assays. | |
APC130Ra02 | Active Noggin (NOG) | Cell culture; Activity Assays. | |
Antibodies | PAC130Ra01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
PAC130Ra02 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. | |
Assay Kits | SEC130Mi | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
HEC130Mi | High Sensitive ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
SEC130Ra | ELISA Kit for Noggin (NOG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC130Ca01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC130Ca01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
LAC130Ca71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
Assay Kits | n/a | CLIA Kit for Noggin (NOG) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Noggin (NOG) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC130Po01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC130Po01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
LAC130Po71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
Assay Kits | n/a | CLIA Kit for Noggin (NOG) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Noggin (NOG) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC130Ga01 | Recombinant Noggin (NOG) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC130Ga01 | Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC; IP. |
LAC130Ga71 | Biotin-Linked Polyclonal Antibody to Noggin (NOG) | WB; IHC; ICC. | |
Assay Kits | n/a | CLIA Kit for Noggin (NOG) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Noggin (NOG) | ELISA Kit Customized Service Offer |