Nibrin (NBN)
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AT-V1; AT-V2; ATV; NBS; NBS1; Nijmegen Breakage Syndrome 1; Cell cycle regulatory protein p95
 HGNC 7652
 MGI 1351625
 PubMed 15668383
 RGD 621420
 UniProt O60934
 USCN C679
 Wiki Nibrin
Nibrin (NBN)
Nibrin is a protein associated with the repair of double strand breaks(DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex.This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).Cellular response is performed by damage sensors, effectors of lesion repair and signal transduction. The central role is carried out by ataxia-telangiectasia mutated(ATM) by activating the DSB signaling cascade, phosphorylating downstream substrates such as histone H2AX and NBS1.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC679Hu01 Recombinant Nibrin (NBN) SDS-PAGE; WB; ELISA; IP.
RPC679Hu02 Recombinant Nibrin (NBN) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC679Hu01 Polyclonal Antibody to Nibrin (NBN) WB, ICC, IHC-P, IHC-F, ELISA
PAC679Hu71 Biotin-Linked Antibody to Nibrin (NBN) IHC;WB;ELISA
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a