Nibrin (NBN)
AT-V1; AT-V2; ATV; NBS; NBS1; Nijmegen Breakage Syndrome 1; Cell cycle regulatory protein p95
Nibrin is a protein associated with the repair of double strand breaks(DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex.This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).Cellular response is performed by damage sensors, effectors of lesion repair and signal transduction. The central role is carried out by ataxia-telangiectasia mutated(ATM) by activating the DSB signaling cascade, phosphorylating downstream substrates such as histone H2AX and NBS1.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC679Hu01 | Recombinant Nibrin (NBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC679Hu02 | Recombinant Nibrin (NBN) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC679Hu01 | Polyclonal Antibody to Nibrin (NBN) | WB; IHC; ICC; IP. |
LAC679Hu71 | Biotin-Linked Polyclonal Antibody to Nibrin (NBN) | WB; IHC; ICC. | |
Assay Kits | n/a | CLIA Kit for Nibrin (NBN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Nibrin (NBN) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Nibrin (NBN) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Nibrin (NBN) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Nibrin (NBN) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Nibrin (NBN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Nibrin (NBN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Nibrin (NBN) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Nibrin (NBN) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Nibrin (NBN) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Nibrin (NBN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Nibrin (NBN) | ELISA Kit Customized Service Offer |