Neutrophil Cytosolic Factor 4 (NCF4)
NCF; P40PHOX; SH3PXD4; Neutrophil NADPH Oxidase Factor 4; SH3 and PX domain-containing protein 4
Neutrophil cytosol factor 4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA328Hu01 | Recombinant Neutrophil Cytosolic Factor 4 (NCF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA328Hu01 | Polyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA328Mu01 | Recombinant Neutrophil Cytosolic Factor 4 (NCF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA328Mu01 | Polyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Neutrophil Cytosolic Factor 4 (NCF4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4) | ELISA Kit Customized Service Offer |