Neuraminidase (NEU)
NEU1; SIAL1; Sialidase 1; Lysosomal Sialidase
 HGNC 7758
 MGI 97305
 RGD 3163
 UniProt Q99519
 USCN B611
Neuraminidase (NEU)
Neuraminidase, or lysosomal sialidase , has a dual physiologic function: it participates in intralysosomal catabolism of sialated glycoconjugates and is involved in cellular immune response. The enzyme occurs in a complex with beta-galactosidase (GLB1) and protective protein/cathepsin A (CTSA).The cDNA predicted a 415-amino acid protein showing extensive homology to other mammalian and bacterial neuraminidases. After the cleavage of a 47-amino acid N-terminal signal peptide and glycosylation, it becomes a 48.3-kD mature active enzyme similar to that found in the multienzyme lysosomal complex. Transient expression of cDNA in deficient human fibroblasts showed that the enzyme is compartmentalized in lysosomes and restores neuraminidase activity in a PPCA-dependent manner.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB611Hu01 Recombinant Neuraminidase (NEU) SDS-PAGE; WB; ELISA; IP.
RPB611Hu02 Recombinant Neuraminidase (NEU) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB611Hu21 Monoclonal Antibody to Neuraminidase (NEU) WB, ICC, IHC-P, IHC-F, ELISA
PAB611Hu01 Polyclonal Antibody to Neuraminidase (NEU) WB, ICC, IHC-P, IHC-F, ELISA
PAB611Hu02 Polyclonal Antibody to Neuraminidase (NEU) WB, ICC, IHC-P, IHC-F, ELISA
PAB611Hu71 Biotin-Linked Antibody to Neuraminidase (NEU) IHC;WB;ELISA
PAB611Hu81 FITC-Linked Antibody to Neuraminidase (NEU) IHC;ICC;IF;WB
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a